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Ubiquinones are a series of homologous molecules that possess a quinone active center and an unsaturated fatty tail. Ubiquinones are so named because they are widely distributed (i.e. ubiquitous) in nature and throughout the human body. Structurally they are very similar to the menaquinones, like vitamin K2. The quinone group is like a courier for protons and electrons, which is the critical property that allows ubiquinones to act as antioxidants and as important intermediates in energy generation. The fatty tail is composed of isoprenoid subunits, which are five carbon building blocks that help all living things biosynthesize critical components like immune modulators, essential oils and hormones. The number of isoprenoid units in the fatty tail is often denoted in the name of specific ubiquinones. For instance, ubiquinone-10 is made from ten isoprenoid units. Ubiquinone-10 (aka CoQ10, coenzyme Q10, Q) is more commonly referred to as just "ubiquinone." This is because it is the most prevalent ubiquinone in almost all mammals, including humans.
Concern about CoQ10 levels is especially important due to concern that cholesterol-lowering drugs (statins) work by inhibiting an enzyme that is also responsible for CoQ10-ubiquinol biosynthesis. As a result, anyone taking statins may have reduced levels of CoQ10-ubiquinol.
What is Ubiquinol?Ubiquinone and ubiquinol (aka ubiquinol-10, CoQ10-H2, QH, "reduced" CoQ10) are intimately related, as their names suggest. Inside the body, Q (ubiquinone) can only achieve its important functions in energy production , cardiovascular health and antioxidant protection with the help of ubiquinol (QH).* In fact, all of the benefits that have been attributed to CoQ10 necessitate QH involvement. The two do their work by shuttling electrons and protons back-and-forth, cyclically transforming from Q to QH and back again. In energy production, CoQ10 facilitates electron transfer within mitochondrial membranes to produce ATP, the body's energy currency.* For antioxidant protection, QH is the "active antioxidant" form of CoQ10. This means that Q that has not been converted to QH is inactive as an antioxidant. Perhaps this explains why circa 80-95 percent of total CoQ10 exists as QH in the blood and in healthy tissues that require its antioxidant function.*
Is Taking QH Better Than Taking Q?CoQ10 is critically obtained from the diet, but it appears that absorption of Q may entail conversion to QH. This conversion occurs as early as in the enterocytes, the absorptive cells in the intestine, and may facilitate the absorption process. Also under normal conditions there are enzymes that help regenerate QH from Q, in the body. Unfortunately, aging and illness can lead to both a reduced ability to regenerate QH because of decreased enzyme activity and a decreased ability to absorb Q itself, possibly for the same reason.
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Size: 120
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- ?Active Antioxidant? Form of Co-Q10
- Q-Absorb High-Absorption System
- Ubiquinol High Absorption Softgel: 2 Dosages: 100 & 200 mg
- Results in Higher Blood Levels Than Co-Q10*: Especially for older consumers
Product Details
Size: 120
- Product Dimensions: 2.7 x 2.7 x 5 inches ; 4.8 ounces
- Shipping Weight: 5.6 ounces (View shipping rates and policies)
- Shipping: Currently, item can be shipped only within the U.S. and to APO/FPO addresses. For APO/FPO shipments, please check with the manufacturer regarding warranty and support issues.
- Origin: USA
- ASIN: B004VCOOUU
- UPC: 790011060253
- Item model number: JAR60253
- Average Customer Review: 4.4 out of 5 stars See all reviews (300 customer reviews)
- Amazon Best Sellers Rank: #234 in Health & Personal Care (See Top 100 in Health & Personal Care)